Dr. Mohamadzadeh’s Lab

 

Dr. Mohamadzadeh is an immunologist with over 25 years of expertise in the fields of inflammation, systemic/mucosal immunology, infection, and vaccine delivery. He is also experienced in working with various therapeutic approaches that focus on the role of innate immune cells–particularly dendritic cells, and how these cells determine the activation and differentiation of T lymphocytes, including T cells, such as TH17 or extrathymic regulatory T cells (Tregs) in steady state, during infection, and throughout autoinflammatory intestinal disorders such as inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC). In his opinion, understanding the molecular mechanisms underlying intestinal immune regulation is most effective when host interactions with intestinal bacterial species and their bacterial products are fully understood, and when the critical molecules that culminate in inflammation or anti-inflammatory responses are identified. Thus, his research is firmly centered on the specifics of beneficial gut microbes, their unique properties, and their role in the induction of stimulatory or regulatory signals in innate cells and T lymphocytes, contributing directly to further proinflammation or regulation of inflammatory diseases (IBD, NEC). Pragmatically, his research is tightly entwined with generating novel therapies for intestinal disorders (e.g. NEC) using beneficial bacteria such as P. UF1 to significantly regulate induced pathogenic inflammation in sufferers who urgently need it.

Current Members

  • Mansour Mohamadzadeh, PhD

  • Bikash Sahay, MVSc, PhD

  • Mojgan Zadeh, MS

  • Natacha Colliou, PhD

  • Yong Ge, PhD

  • Jennifer Owen, DVM, PhD

  • Minghao Gong, BS

    • Melissa Valletti
    • Max Van Belkum